Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

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Citation

Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR

Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

Genomics. 2001 Sep;77(1-2):58-64.

PubMed ID
11543633 [ View in PubMed
]
Abstract

We have identified LASS2, a previously unknown human homologue of the yeast longevity assurance gene LAG1. The LASS2 transcript is highly expressed in liver and kidney, which is very different from the expression of the previously identified human LAG1 homologue LAG1Hs-1. Radiation hybrid mapping studies indicated that LASS2 is located on chromosome 1q11. Yeast two-hybrid screening and glutathione S-transferase pull-down assays showed that the LASS2 protein interacts with several membrane-associated receptors or transporters. Furthermore, LASS2 protein was able to inhibit the colony formation of human hepatoma cells in vitro, which suggests that this gene may be involved in the regulation of cell growth.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Asialoglycoprotein receptor 2P07307Details
V-type proton ATPase 16 kDa proteolipid subunit cP27449Details
Asialoglycoprotein receptor 1P07306Details