Epithelial sodium channel subunit beta

BE0000024ProteinHumansSCNN1B

This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). It is acted on by 4 drugs in DrugBank.

Gene name
SCNN1B
UniProtKB entry
P51168Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
640 residues · 72,658 Da
Also known as
Amiloride-sensitive sodium channel subunit beta · Beta-ENaC · Beta-NaCH · ENaC subunit beta · ENaCB

Resolves to

Protein
UniProtP51168UniProt nameSCNNB_HUMAN
Gene
HGNCHGNC:10600NCBI Gene6338GenBank1004271GeneCardsSCNN1B
Pharmacology
IUPHAR/GtoPdb739KEGGhsa:6338
Structure
PDB6BQNPDB6WTHPDB9BLR
Drugs

What you can answer from here — as of February 11, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epithelial sodium channel subunit beta, how selective are they, and which programs against it are still in active trials?

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