Delta-aminolevulinic acid dehydratase

BE0000050ProteinHumansALAD

Catalyzes an early step in the biosynthesis of tetrapyrroles. It is acted on by 15 drugs in DrugBank.

Gene name
ALAD
UniProtKB entry
P13716Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
330 residues · 36,294 Da
Also known as
4.2.1.24 · ALADH · Porphobilinogen synthase

Resolves to

Protein
UniProtP13716UniProt nameHEM2_HUMAN
Gene
HGNCHGNC:395NCBI Gene210GenBank178329GeneCardsALAD
Pharmacology
KEGGhsa:210
Structure
PDB1E51PDB1PV8PDB5HMS
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Delta-aminolevulinic acid dehydratase, how selective are they, and which programs against it are still in active trials?

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