Glycine receptor subunit beta

BE0000055ProteinHumansGLRB

Subunit of heteromeric glycine-gated chloride channels (PubMed:11929858, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:23238346, PubMed:25445488, PubMed:34473954, PubMed:8717357). It is acted on by 11 drugs in DrugBank.

Gene name
GLRB
UniProtKB entry
P48167Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
497 residues · 56,122 Da
Also known as
Glycine receptor 58 kDa subunit

Resolves to

Protein
UniProtP48167UniProt nameGLRB_HUMAN
Gene
HGNCHGNC:4329NCBI Gene2743GenBank992687GeneCardsGLRB
Pharmacology
IUPHAR/GtoPdb427KEGGhsa:2743
Structure
PDB5BKFPDB5BKGPDB7KUY
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine receptor subunit beta, how selective are they, and which programs against it are still in active trials?

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