This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Strychnine
DrugBank Accession Number
DB15954
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 334.419
Monoisotopic: 334.168127956
Chemical Formula
C21H22N2O2
Synonyms
  • Stricnina
  • Strychnidin-10-one
  • Strychnin
External IDs
  • 200-319-7
  • NSC-5365

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Strychnine nitrateO642E9671166-32-0PCGVPMHGSJFFTI-ZEYGOCRCSA-N
Strychnine sulfateFA486DV76S60-41-3GOOCRIHPADOQAS-ZNUXJMJHSA-N

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
H9Y79VD43J
CAS number
57-24-9
InChI Key
QMGVPVSNSZLJIA-FVWCLLPLSA-N
InChI
InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
IUPAC Name
(1R,11S,18S,20R,21R,22S)-12-oxa-8,17-diazaheptacyclo[15.5.2.0^{1,18}.0^{2,7}.0^{8,22}.0^{11,21}.0^{15,20}]tetracosa-2,4,6,14-tetraen-9-one
SMILES
[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6C7=CC=CC=C7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H]

References

General References
Not Available
KEGG Compound
C06522
ChemSpider
389877
BindingDB
50225707
RxNav
66422
ChEBI
28973
ChEMBL
CHEMBL227934
ZINC
ZINC000000119434
PDBe Ligand
SY9
Wikipedia
Strychnine
PDB Entries
2xys / 3jad / 5cfb / 5o8t / 5oa0 / 5oal / 5obg / 7kuy / 7l31

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.72 mg/mLALOGPS
logP1.68ALOGPS
logP0.93ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)17.24ChemAxon
pKa (Strongest Basic)9.27ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area32.78 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity94.51 m3·mol-1ChemAxon
Polarizability35.9 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at November 26, 2020 20:34 / Updated at February 13, 2021 11:03