Prolyl 4-hydroxylase subunit alpha-1

BE0000060ProteinHumansP4HA1

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. It is acted on by 5 drugs in DrugBank.

Gene name
P4HA1
UniProtKB entry
P13674Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
534 residues · 61,049 Da
Also known as
1.14.11.2 · 4-PH alpha-1 · P4HA · Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1

Resolves to

Protein
UniProtP13674UniProt nameP4HA1_HUMAN
Gene
HGNCHGNC:8546NCBI Gene5033GenBank190786GeneCardsP4HA1
Pharmacology
KEGGhsa:5033
Structure
PDB1TJCPDB2V5FPDB2YQ8
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl 4-hydroxylase subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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