B-lymphocyte antigen CD20

BE0000066ProteinHumansMS4A1

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). It is acted on by 29 drugs in DrugBank.

Gene name
MS4A1
UniProtKB entry
P11836Swiss-Prot
Cellular location
Cell membrane
Residues / weight
297 residues · 33,077 Da
Also known as
B-lymphocyte surface antigen B1 · Bp35 · CD20 · Leukocyte surface antigen Leu-16 · Membrane-spanning 4-domains subfamily A member 1

Resolves to

Protein
UniProtP11836UniProt nameCD20_HUMAN
Gene
HGNCHGNC:7315NCBI Gene931GenBank29774GeneCardsMS4A1
Pharmacology
IUPHAR/GtoPdb2628KEGGhsa:931
Structure
PDB2OSLPDB3BKYPDB3PP4
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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257Clinical trialsTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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137+ReferencesStructured and connected to the statements they support
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Which approved drugs act on B-lymphocyte antigen CD20, how selective are they, and which programs against it are still in active trials?

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