Technetium Tc-99m nofetumomab merpentan (Tc-99m nm) consists of a Fab fragment of an IgG2b of the pancarcinoma murine antibody NR-LU-10. The NR-LU-10 antibody is directed against a 40 kDa glycoprotein... The NR-LU-10 antibody is directed against a 40 kDa glycoprotein antigen expressed in a variety of cancers and some normal tissues.
- Mechanism
- Curator reviewed · 2 references
The mechanism of action in Tc-99m nm is ruled by the presence of nofetumomab, which can recognize the pancarcinoma antigen EpCAM and/or CD20/MS4A1, and merpentan, that acts as a linker for the binding of technetium.
- Primary indication
- Tc-99m nm is one of the technetium-labeled antibodies and it is indicated for the detection of small-cell lung cancer.Curator reviewed
- Also known as
- Nofetumomab · Technetium (99mTc) nofetumomab merpentan · Technetium Tc 99m nofetumomab merpentan
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with Technetium Tc-99m nofetumomab merpentan, and which of those have an active Phase 3 trial?
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