S-adenosylmethionine decarboxylase proenzyme

BE0000101ProteinHumansAMD1

Essential for biosynthesis of the polyamines spermidine and spermine. It is acted on by 6 drugs in DrugBank.

Gene name
AMD1
UniProtKB entry
P17707Swiss-Prot
Residues / weight
334 residues · 38,339 Da
Also known as
4.1.1.50 · AdoMetDC · AMD · SAMDC

Resolves to

Protein
UniProtP17707UniProt nameDCAM_HUMAN
Gene
HGNCHGNC:457NCBI Gene262GenBank178518GeneCardsAMD1
Pharmacology
KEGGhsa:262
Structure
PDB1I72PDB1I79PDB1I7B
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on S-adenosylmethionine decarboxylase proenzyme, how selective are they, and which programs against it are still in active trials?

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