Tromethamine

DB03754ApprovedInvestigationalSmall molecule

Tromethamine is a proton acceptor used for the prevention and correction of metabolic acidosis associated with various clinical conditions, such as cardiac bypass surgery. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer.

Chemical structure of Tromethamine
Primary indication
For the prevention and correction of metabolic acidosis.Curator reviewed · 2 structured indications
Formula / weight
C4H11NO3 · 121.135 g/mol (avg)
First approval
Canada, 2004 · United States, 2020
Also known as
THAM · Tris · Trometamol
Code names
NSC-6365

Resolves to

Compound
UNII023C2WHX2VCAS77-86-1ChEMBLCHEMBL1200391ChEBI9754PubChem6503KEGGD00396
Clinical / RWD
RxNorm10865ATCB05BB03ATCB05XX02
Structure
InChIKeyLENZDBCJOHFCAS-UHFFFAOYSA-NSMILESNC(CO)(CO)CO
Targets
P17707AMD1P05067APP

What you can answer from here — as of September 30, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
5Drug interactionsStructured to mechanism, not free text
Sign in
18Clinical trialsPhase, status and sponsor resolved per trial
Sign in
2Structured indicationsCondition, population, route and combination as fields, not prose
Sign in
5ContraindicationsEach with its own population and attribute set
Sign in
7Marketed productsAcross 3 countries and 6 labellers
Sign in
2ATC codesIncluding every combination product, plus 16 drug categories
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which drugs share a target with Tromethamine, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In