Adenine phosphoribosyltransferase

BE0000115ProteinHumansAPRT

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. It is acted on by 7 drugs in DrugBank.

Gene name
APRT
UniProtKB entry
P07741Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
180 residues · 19,608 Da
Also known as
2.4.2.7 · APRT

Resolves to

Protein
UniProtP07741UniProt nameAPT_HUMAN
Gene
HGNCHGNC:626NCBI Gene353GenBank28819GeneCardsAPRT
Pharmacology
KEGGhsa:353
Structure
PDB1OREPDB1ZN7PDB1ZN8
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenine phosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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