Phospholipid-transporting ATPase ABCA1

BE0000119ProteinHumansABCA1

Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). It is acted on by 9 drugs in DrugBank.

Gene name
ABCA1
UniProtKB entry
O95477Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,261 residues · 254,300 Da
Also known as
7.6.2.1 · ABC-1 · ABC1 · ATP-binding cassette 1 · ATP-binding cassette sub-family A member 1

Resolves to

Protein
UniProtO95477UniProt nameABCA1_HUMAN
Gene
HGNCHGNC:29NCBI Gene19GenBank9247086GeneCardsABCA1
Pharmacology
KEGGhsa:19
Structure
PDB5XJYPDB7ROQPDB7TBW
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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34GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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71+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipid-transporting ATPase ABCA1, how selective are they, and which programs against it are still in active trials?

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