Epithelial sodium channel subunit alpha

BE0000190ProteinHumansSCNN1A

This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:8023962, PubMed:8278374, PubMed:9792722). It is acted on by 6 drugs in DrugBank.

Gene name
SCNN1A
UniProtKB entry
P37088Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
669 residues · 75,703 Da
Also known as
Alpha-ENaC · Alpha-NaCH · Amiloride-sensitive sodium channel subunit alpha · ENaC subunit alpha · ENaCA

Resolves to

Protein
UniProtP37088UniProt nameSCNNA_HUMAN
Gene
HGNCHGNC:10599NCBI Gene6337GenBank452650GeneCardsSCNN1A
Pharmacology
IUPHAR/GtoPdb738KEGGhsa:6337
Structure
PDB2M3OPDB6BQNPDB6WTH
Drugs

What you can answer from here — as of February 11, 2025

6DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epithelial sodium channel subunit alpha, how selective are they, and which programs against it are still in active trials?

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