Calcium-transporting ATPase type 2C member 1

BE0000218ProteinHumansATP2C1

ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). It is acted on by 4 drugs in DrugBank.

Gene name
ATP2C1
UniProtKB entry
P98194Swiss-Prot
Cellular location
Golgi apparatus, trans-Golgi network membrane
Residues / weight
919 residues · 100,576 Da
Also known as
7.2.2.10 · ATP-dependent Ca(2+) pump PMR1 · ATPase 2C1 · Ca(2+)/Mn(2+)-ATPase 2C1 · KIAA1347

Resolves to

Protein
UniProtP98194UniProt nameAT2C1_HUMAN
Gene
HGNCHGNC:13211NCBI Gene27032GenBank6715131GeneCardsATP2C1
Pharmacology
KEGGhsa:27032
Structure
PDB7YAGPDB7YAHPDB7YAI
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
18+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Calcium-transporting ATPase type 2C member 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In