5'-AMP-activated protein kinase subunit beta-1

BE0000254ProteinHumansPRKAB1

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. It is acted on by 9 drugs in DrugBank.

Gene name
PRKAB1
UniProtKB entry
Q9Y478Swiss-Prot
Residues / weight
270 residues · 30,382 Da
Also known as
AMPK · AMPK subunit beta-1 · AMPKb

Resolves to

Protein
UniProtQ9Y478UniProt nameAAKB1_HUMAN
Gene
HGNCHGNC:9378NCBI Gene5564GenBank2916800GeneCardsPRKAB1
Pharmacology
IUPHAR/GtoPdb1543KEGGhsa:5564
Structure
PDB4CFEPDB4CFFPDB4ZHX
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5'-AMP-activated protein kinase subunit beta-1, how selective are they, and which programs against it are still in active trials?

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