DNA-directed RNA polymerase subunit beta

BE0000257ProteinEscherichia coli (strain K12)rpoB

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 6 drugs in DrugBank.

Gene name
rpoB
UniProtKB entry
P0A8V2Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
1,342 residues · 150,631 Da
Also known as
2.7.7.6 · groN · nitB · rif · RNA polymerase subunit beta

Resolves to

Protein
UniProtP0A8V2UniProt nameRPOB_ECOLI
Gene
NCBI Gene948488GenBank42818
Pharmacology
KEGGecj:JW3950
Structure
PDB3IYDPDB3LTIPDB3LU0
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
6Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA-directed RNA polymerase subunit beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In