Antithrombin-III

BE0000280ProteinHumansSERPINC1

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). It is acted on by 20 drugs in DrugBank.

Gene name
SERPINC1
UniProtKB entry
P01008Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
464 residues · 52,602 Da
Also known as
AT3 · ATIII · Serpin C1

Resolves to

Protein
UniProtP01008UniProt nameANT3_HUMAN
Gene
HGNCHGNC:775NCBI Gene462GenBank179161GeneCardsSERPINC1
Pharmacology
IUPHAR/GtoPdb2632KEGGhsa:462
Structure
PDB1ANTPDB1ATHPDB1AZX
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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118+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Antithrombin-III, how selective are they, and which programs against it are still in active trials?

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