Solute carrier family 12 member 2

BE0000281ProteinHumansSLC12A2

Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). It is acted on by 8 drugs in DrugBank.

Gene name
SLC12A2
UniProtKB entry
P55011Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,212 residues · 131,446 Da
Also known as
Basolateral Na-K-Cl symporter · BSC2 · Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 · hNKCC1 · Na-K-2Cl cotransporter 1

Resolves to

Protein
UniProtP55011UniProt nameS12A2_HUMAN
Gene
HGNCHGNC:10911NCBI Gene6558GenBank903682GeneCardsSLC12A2
Pharmacology
IUPHAR/GtoPdb969KEGGhsa:6558
Structure
PDB6PZTPDB7D10PDB7MXO
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 2, how selective are they, and which programs against it are still in active trials?

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