Thyroid hormone receptor beta

BE0000315ProteinHumansTHRB

Nuclear hormone receptor that can act as a repressor or activator of transcription. It is acted on by 17 drugs in DrugBank.

Gene name
THRB
UniProtKB entry
P10828Swiss-Prot
Cellular location
Nucleus
Residues / weight
461 residues · 52,787 Da
Also known as
c-erbA-2 · c-erbA-beta · ERBA2 · NR1A2 · Nuclear receptor subfamily 1 group A member 2

Resolves to

Protein
UniProtP10828UniProt nameTHB_HUMAN
Gene
HGNCHGNC:11799NCBI Gene7068GenBank31207GeneCardsTHRB
Pharmacology
IUPHAR/GtoPdb589KEGGhsa:7068
Structure
PDB1BSXPDB1N46PDB1NAX
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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105+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thyroid hormone receptor beta, how selective are they, and which programs against it are still in active trials?

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