Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix... Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion.
- Mechanism
- Curator reviewed
The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major secreted form of thyroid hormone is T4. T4 is converted T3, the more active thyroid hormone, by deiodinases in peripheral tissues. T3 acts in the body to increase basal metabolic rate, alter protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). Thyroid hormones are essential for proper development and differentiation of all cells of the human body. T4 and T3 regulate protein, fat and carbohydrate metabolism to varying extents. The most pronounced effect of the hormones is in altering how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects.
- Primary indication
- May be used to treat primary, secondary or tertiary hypothyroidism.Curator reviewed
- Formula / weight
- C30H21I7N2Na2O8 · 1471.8072 g/mol (avg)
- Also known as
- Levothyroxine Sodium mixture with Liothyronine Sodium · Liotrix (T4;T3)
- Code names
- W 1782
Resolves to
LKYWLLWWYBVUPP-XOCLESOZSA-LSMILES[Na+].[Na+].N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C([O-])=O.N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C([O-])=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Liotrix, and which of those have an active Phase 3 trial?
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