Diamine oxidase [copper-containing]

BE0000351ProteinHumansAOC1

Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). It is acted on by 8 drugs in DrugBank.

Gene name
AOC1
UniProtKB entry
P19801Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
751 residues · 85,377 Da
Also known as
1.4.3.22 · ABP · ABP1 · Amiloride-binding protein · Amiloride-binding protein 1

Resolves to

Protein
UniProtP19801UniProt nameAOC1_HUMAN
Gene
HGNCHGNC:80NCBI Gene26GenBank177960GeneCardsAOC1
Pharmacology
KEGGhsa:26
Structure
PDB3HI7PDB3HIGPDB3HII
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Diamine oxidase [copper-containing], how selective are they, and which programs against it are still in active trials?

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