Interferon alpha/beta receptor 2

BE0000385ProteinHumansIFNAR2

Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). It is acted on by 13 drugs in DrugBank.

Gene name
IFNAR2
UniProtKB entry
P48551Swiss-Prot
Cellular location
Cell membrane
Residues / weight
515 residues · 57,758 Da
Also known as
IFN-alpha binding protein · IFN-alpha/beta receptor 2 · IFN-R-2 · IFNABR · IFNARB

Resolves to

Protein
UniProtP48551UniProt nameINAR2_HUMAN
Gene
HGNCHGNC:5433NCBI Gene3455GenBank995300GeneCardsIFNAR2
Pharmacology
KEGGhsa:3455
Structure
PDB1N6UPDB1N6VPDB2HYM
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interferon alpha/beta receptor 2, how selective are they, and which programs against it are still in active trials?

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