Calcitonin receptor

BE0000431ProteinHumansCALCR

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). It is acted on by 5 drugs in DrugBank.

Gene name
CALCR
UniProtKB entry
P30988Swiss-Prot
Cellular location
Cell membrane
Residues / weight
474 residues · 55,344 Da
Also known as
CT-R

Resolves to

Protein
UniProtP30988UniProt nameCALCR_HUMAN
Gene
HGNCHGNC:1440NCBI Gene799GenBank179880GeneCardsCALCR
Pharmacology
IUPHAR/GtoPdb43KEGGhsa:799
Structure
PDB5II0PDB5UZ7PDB6NIY
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcitonin receptor, how selective are they, and which programs against it are still in active trials?

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