Salmon calcitonin is a synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease. Synthetic peptide, 32 residues long formulated as a nasal spray.
- Mechanism
- Curator reviewed
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
- Primary indication
- Used in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments.Curator reviewed · 5 structured indications
- Formula / weight
- C145H240N44O48S2 · 3431.853 Da
- First approval
- Canada, 1998 · United States, 1986
- Also known as
- Calcitonin (Salmon Synthetic) · Calcitonin salmon · Calcitonin salmon recombinant · Calcitonin-salmon · Calcitonin, salmon
- Code names
- SMC-021
- Brand names
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Salmon calcitonin, and which of those have an active Phase 3 trial?
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