cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

BE0000436ProteinHumansPDE3A

Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). It is acted on by 21 drugs in DrugBank.

Gene name
PDE3A
UniProtKB entry
Q14432Swiss-Prot
Cellular location
Membrane
Residues / weight
1,141 residues · 124,978 Da
Also known as
3.1.4.17 · cGI-PDE · CGI-PDE A · cGMP-inhibited cAMP phosphodiesterase · Cyclic GMP-inhibited phosphodiesterase A

Resolves to

Protein
UniProtQ14432UniProt namePDE3A_HUMAN
Gene
HGNCHGNC:8778NCBI Gene5139GenBank38201493GeneCardsPDE3A
Pharmacology
IUPHAR/GtoPdb1298KEGGhsa:5139
Structure
PDB7EG0PDB7EG1PDB7EG4
Drugs

What you can answer from here — as of September 03, 2024

21DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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81+ReferencesStructured and connected to the statements they support
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Which approved drugs act on cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, how selective are they, and which programs against it are still in active trials?

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