Oxtriphylline is a bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Oxtriphylline is the choline salt form of theophylline.
- Mechanism
- Curator reviewed
Oxtriphylline is a choline salt of theophylline. After ingestion, theophylline is released from oxytriphylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
- Primary indication
- Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.Curator reviewed · 4 structured indications
- Formula / weight
- C12H21N5O3 · 283.3268 g/mol (avg)
- First approval
- Canada, 2005
- Also known as
- Choline theophyllinate · Choline theophylline · Theocolin
Resolves to
RLANKEDHRWMNRO-UHFFFAOYSA-MSMILESC[N+](C)(C)CCO.CN1C2=C([N-]C=N2)C(=O)N(C)C1=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Oxtriphylline, and which of those have an active Phase 3 trial?
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