Integrin alpha-IIb

BE0000439ProteinHumansITGA2B

Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It is acted on by 16 drugs in DrugBank.

Gene name
ITGA2B
UniProtKB entry
P08514Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,039 residues · 113,376 Da
Also known as
GP2B · GPalpha IIb · GPIIb · ITGAB · Platelet membrane glycoprotein IIb

Resolves to

Protein
UniProtP08514UniProt nameITA2B_HUMAN
Gene
HGNCHGNC:6138NCBI Gene3674GenBank190068GeneCardsITGA2B
Pharmacology
IUPHAR/GtoPdb2441KEGGhsa:3674
Structure
PDB1DPKPDB1DPQPDB1KUP
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
12GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
86+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Integrin alpha-IIb, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In