Epithelial sodium channel subunit gamma

BE0000497ProteinHumansSCNN1G

This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7550319, PubMed:7762608, PubMed:9792722). It is acted on by 4 drugs in DrugBank.

Gene name
SCNN1G
UniProtKB entry
P51170Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
649 residues · 74,270 Da
Also known as
Amiloride-sensitive sodium channel subunit gamma · ENaC subunit gamma · ENaCG · Epithelial Na(+) channel subunit gamma · Gamma-ENaC

Resolves to

Protein
UniProtP51170UniProt nameSCNNG_HUMAN
Gene
HGNCHGNC:10602NCBI Gene6340GenBank1004273GeneCardsSCNN1G
Pharmacology
IUPHAR/GtoPdb741KEGGhsa:6340
Structure
PDB6BQNPDB6WTHPDB9BLR
Drugs

What you can answer from here — as of February 11, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
29+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Epithelial sodium channel subunit gamma, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In