NADH-ubiquinone oxidoreductase chain 1

BE0000503ProteinHumansMT-ND1

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:1959619). It is acted on by 10 drugs in DrugBank.

Gene name
MT-ND1
UniProtKB entry
P03886Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
318 residues · 35,660 Da
Also known as
7.1.1.2 · MTND1 · NADH dehydrogenase subunit 1 · NADH1 · ND1

Resolves to

Protein
UniProtP03886UniProt nameNU1M_HUMAN
Gene
HGNCHGNC:7455NCBI Gene4535GenBank13004GeneCardsMT-ND1
Pharmacology
KEGGhsa:4535
Structure
PDB5XTCPDB5XTDPDB9CWT
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH-ubiquinone oxidoreductase chain 1, how selective are they, and which programs against it are still in active trials?

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