Integrin alpha-L

BE0000516ProteinHumansITGAL

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:10846180, PubMed:12526797, PubMed:1676048, PubMed:3086451). It is acted on by 13 drugs in DrugBank.

Gene name
ITGAL
UniProtKB entry
P20701Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,170 residues · 128,768 Da
Also known as
CD11 antigen-like family member A · CD11A · Leukocyte adhesion glycoprotein LFA-1 alpha chain · Leukocyte function-associated molecule 1 alpha chain · LFA-1A

Resolves to

Protein
UniProtP20701UniProt nameITAL_HUMAN
Gene
HGNCHGNC:6148NCBI Gene3683GenBank31422GeneCardsITGAL
Pharmacology
IUPHAR/GtoPdb2451KEGGhsa:3683
Structure
PDB1CQPPDB1DGQPDB1LFA
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin alpha-L, how selective are they, and which programs against it are still in active trials?

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