Vitamin D 25-hydroxylase

BE0000524ProteinHumansCYP2R1

A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. It is acted on by 3 drugs in DrugBank.

Gene name
CYP2R1
UniProtKB entry
Q6VVX0Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
501 residues · 57,359 Da
Also known as
1.14.14.24 · Cytochrome P450 2R1

Resolves to

Protein
UniProtQ6VVX0UniProt nameCP2R1_HUMAN
Gene
HGNCHGNC:20580NCBI Gene120227GenBank33591222GeneCardsCYP2R1
Pharmacology
KEGGhsa:120227
Structure
PDB3C6GPDB3CZHPDB3DL9
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin D 25-hydroxylase, how selective are they, and which programs against it are still in active trials?

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