Aspartate aminotransferase, cytoplasmic

BE0000529ProteinHumansGOT1

Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). It is acted on by 11 drugs in DrugBank.

Gene name
GOT1
UniProtKB entry
P17174Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
413 residues · 46,247 Da
Also known as
2.6.1.1 · 2.6.1.3 · cAspAT · cCAT · Cysteine aminotransferase, cytoplasmic

Resolves to

Protein
UniProtP17174UniProt nameAATC_HUMAN
Gene
HGNCHGNC:4432NCBI Gene2805GenBank179067GeneCardsGOT1
Pharmacology
KEGGhsa:2805
Structure
PDB3II0PDB3WZFPDB6DNA
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
28GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Aspartate aminotransferase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In