DNA polymerase alpha catalytic subunit

BE0000546ProteinHumansPOLA1

Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. It is acted on by 6 drugs in DrugBank.

Gene name
POLA1
UniProtKB entry
P09884Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,462 residues · 165,911 Da
Also known as
2.7.7.7 · DNA polymerase alpha catalytic subunit p180 · POLA

Resolves to

Protein
UniProtP09884UniProt nameDPOLA_HUMAN
Gene
HGNCHGNC:9173NCBI Gene5422GenBank35568GeneCardsPOLA1
Pharmacology
KEGGhsa:5422
Structure
PDB1K0PPDB1K18PDB1N5G
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase alpha catalytic subunit, how selective are they, and which programs against it are still in active trials?

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