Atrial natriuretic peptide receptor 1

BE0000556ProteinHumansNPR1

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). It is acted on by 12 drugs in DrugBank.

Gene name
NPR1
UniProtKB entry
P16066Swiss-Prot
Cellular location
Membrane
Residues / weight
1,061 residues · 118,918 Da
Also known as
4.6.1.2 · ANP-A · ANPR-A · ANPRA · Atrial natriuretic peptide receptor type A

Resolves to

Protein
UniProtP16066UniProt nameANPRA_HUMAN
Gene
HGNCHGNC:7943NCBI Gene4881GenBank28230GeneCardsNPR1
Pharmacology
IUPHAR/GtoPdb1747KEGGhsa:4881
Structure
PDB8TG9PDB8TGAPDB9BCL
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Atrial natriuretic peptide receptor 1, how selective are they, and which programs against it are still in active trials?

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