Squalene monooxygenase

BE0000577ProteinHumansSQLE

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. It is acted on by 9 drugs in DrugBank.

Gene name
SQLE
UniProtKB entry
Q14534Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
574 residues · 63,923 Da
Also known as
1.14.14.17 · ERG1 · SE · Squalene epoxidase

Resolves to

Protein
UniProtQ14534UniProt nameERG1_HUMAN
Gene
HGNCHGNC:11279NCBI Gene6713GenBank2443316GeneCardsSQLE
Pharmacology
IUPHAR/GtoPdb2433KEGGhsa:6713
Structure
PDB6C6NPDB6C6PPDB6C6R
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Squalene monooxygenase, how selective are they, and which programs against it are still in active trials?

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