Naftifine is an antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species. A medication used to treat certain infections caused by fungus.
- Mechanism
- Curator reviewed
Although the exact mechanism of action against fungi is not known, naftifine appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.
- Primary indication
- For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.Curator reviewed · 5 structured indications
- Formula / weight
- C21H21N · 287.3981 g/mol (avg)
- First approval
- Canada, 1993 · United States, 1990
- Code names
- AW 105 843 · NAFT-500 · SN 105843
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
OZGNYLLQHRPOBR-DHZHZOJOSA-NSMILESCN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12Targets
What you can answer from here — as of September 13, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Naftifine, and which of those have an active Phase 3 trial?
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