Acetyl-CoA carboxylase 1

BE0000626ProteinHumansACACA

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). It is acted on by 5 drugs in DrugBank.

Gene name
ACACA
UniProtKB entry
Q13085Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
2,346 residues · 265,552 Da
Also known as
6.4.1.2 · ACAC · ACC-alpha · ACC1 · ACCA

Resolves to

Protein
UniProtQ13085UniProt nameACACA_HUMAN
Gene
HGNCHGNC:84NCBI Gene31GenBank849083GeneCardsACACA
Pharmacology
IUPHAR/GtoPdb1263KEGGhsa:31
Structure
PDB2YL2PDB3COJPDB4ASI
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetyl-CoA carboxylase 1, how selective are they, and which programs against it are still in active trials?

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