J147

DB13957ExperimentalSmall molecule

J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and... It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.

Mechanism: Pharmacologically active on 5-hydroxytryptamine receptor 1A, Acetyl-CoA carboxylase 1, and Amine oxidase [flavin-containing] A
Curator reviewed
Formula / weight: C₁₈H₁₇F₃N₂O₂ · 350.341 g/mol (avg)
Code names: J147

Resolves to

Compound

UNIIZ41H3C5BT9CAS1146963-51-0ChEMBLCHEMBL2387144

Structure

InChIKeyHYMZAYGFKNNHDN-SSDVNMTOSA-NSMILESCOC1=CC(\C=N\N(C(=O)C(F)(F)F)C2=C(C)C=C(C)C=C2)=CC=C1

Targets

P08908HTR1AQ13085ACACAP21397MAOA

What you can answer from here — as of July 07, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with J147, and which of those have an active Phase 3 trial?

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