cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

BE0000631ProteinHumansPDE10A

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447). It is acted on by 16 drugs in DrugBank.

Gene name
PDE10A
UniProtKB entry
Q9Y233Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,055 residues · 114,945 Da
Also known as
3.1.4.17

Resolves to

Protein
UniProtQ9Y233UniProt namePDE10_HUMAN
Gene
HGNCHGNC:8772NCBI Gene10846GenBank4958858GeneCardsPDE10A
Pharmacology
IUPHAR/GtoPdb1310KEGGhsa:10846
Structure
PDB2OUNPDB2OUPPDB2OUQ
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, how selective are they, and which programs against it are still in active trials?

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