Long-chain-fatty-acid--CoA ligase 1

BE0000639ProteinHumansACSL1

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). It is acted on by 3 drugs in DrugBank.

Gene name
ACSL1
UniProtKB entry
P33121Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
698 residues · 77,943 Da
Also known as
6.2.1.3 · ACS1 · Acyl-CoA synthetase 1 · Arachidonate--CoA ligase · FACL1

Resolves to

Protein
UniProtP33121UniProt nameACSL1_HUMAN
Gene
HGNCHGNC:3569NCBI Gene2180GenBank219900GeneCardsACSL1
Pharmacology
KEGGhsa:2180
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
14+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Long-chain-fatty-acid--CoA ligase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In