Activin receptor type-1B

BE0000665ProteinHumansACVR1B

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). It is acted on by 3 drugs in DrugBank.

Gene name
ACVR1B
UniProtKB entry
P36896Swiss-Prot
Cellular location
Cell membrane
Residues / weight
505 residues · 56,806 Da
Also known as
2.7.11.30 · Activin receptor type IB · Activin receptor-like kinase 4 · ACTR-IB · ACVRLK4

Resolves to

Protein
UniProtP36896UniProt nameACV1B_HUMAN
Gene
HGNCHGNC:172NCBI Gene91GenBank402189GeneCardsACVR1B
Pharmacology
IUPHAR/GtoPdb1787KEGGhsa:91
Structure
PDB7MRZPDB7OLY
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Activin receptor type-1B, how selective are they, and which programs against it are still in active trials?

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