Thyroid hormone receptor alpha

BE0000687ProteinHumansTHRA

Nuclear hormone receptor that can act as a repressor or activator of transcription. It is acted on by 10 drugs in DrugBank.

Gene name
THRA
UniProtKB entry
P10827Swiss-Prot
Cellular location
Nucleus
Residues / weight
490 residues · 54,815 Da
Also known as
c-erbA-1 · c-erbA-alpha · EAR-7 · EAR7 · ERBA1

Resolves to

Protein
UniProtP10827UniProt nameTHA_HUMAN
Gene
HGNCHGNC:11796NCBI Gene7067GenBank825639GeneCardsTHRA
Pharmacology
IUPHAR/GtoPdb588KEGGhsa:7067
Structure
PDB1NAVPDB2H77PDB2H79
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thyroid hormone receptor alpha, how selective are they, and which programs against it are still in active trials?

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