Voltage-dependent calcium channel subunit alpha-2/delta-1

BE0000691ProteinHumansCACNA2D1

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). It is acted on by 21 drugs in DrugBank.

Gene name
CACNA2D1
UniProtKB entry
P54289Swiss-Prot
Cellular location
Membrane
Residues / weight
1,103 residues · 124,567 Da
Also known as
CACNL2A · CCHL2A · MHS3 · Voltage-gated calcium channel subunit alpha-2/delta-1

Resolves to

Protein
UniProtP54289UniProt nameCA2D1_HUMAN
Gene
HGNCHGNC:1399NCBI Gene781GenBank179762GeneCardsCACNA2D1
Pharmacology
KEGGhsa:781
Structure
PDB7MIXPDB7MIYPDB7UHF
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent calcium channel subunit alpha-2/delta-1, how selective are they, and which programs against it are still in active trials?

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