Indoleamine 2,3-dioxygenase 1

BE0000693ProteinHumansIDO1

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174, PubMed:18026683). It is acted on by 12 drugs in DrugBank.

Gene name
IDO1
UniProtKB entry
P14902Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
403 residues · 45,326 Da
Also known as
1.13.11.52 · IDO · IDO-1 · INDO · Indoleamine-pyrrole 2,3-dioxygenase

Resolves to

Protein
UniProtP14902UniProt nameI23O1_HUMAN
Gene
HGNCHGNC:6059NCBI Gene3620GenBank306956GeneCardsIDO1
Pharmacology
IUPHAR/GtoPdb2829KEGGhsa:3620
Structure
PDB2D0TPDB2D0UPDB4PK5
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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26Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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66+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Indoleamine 2,3-dioxygenase 1, how selective are they, and which programs against it are still in active trials?

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