Branched-chain-amino-acid aminotransferase, mitochondrial

BE0000721ProteinHumansBCAT2

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:17050531, PubMed:25653144, PubMed:8702755). It is acted on by 8 drugs in DrugBank.

Gene name
BCAT2
UniProtKB entry
O15382Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
392 residues · 44,287 Da
Also known as
2.6.1.42 · BCAT(m) · BCATM · BCT2 · ECA40

Resolves to

Protein
UniProtO15382UniProt nameBCAT2_HUMAN
Gene
HGNCHGNC:977NCBI Gene587GenBank2342862GeneCardsBCAT2
Pharmacology
IUPHAR/GtoPdb2893KEGGhsa:587
Structure
PDB1EKFPDB1EKPPDB1EKV
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Branched-chain-amino-acid aminotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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