Inosine-5'-monophosphate dehydrogenase 2

BE0000722ProteinHumansIMPDH2

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of... It is acted on by 11 drugs in DrugBank.

Gene name
IMPDH2
UniProtKB entry
P12268Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
514 residues · 55,804 Da
Also known as
1.1.1.205 · IMP dehydrogenase 2 · IMP dehydrogenase II · IMPD 2 · IMPD2

Resolves to

Protein
UniProtP12268UniProt nameIMDH2_HUMAN
Gene
HGNCHGNC:6053NCBI Gene3615GenBank307066GeneCardsIMPDH2
Pharmacology
IUPHAR/GtoPdb2625KEGGhsa:3615
Structure
PDB1B3OPDB1NF7PDB1NFB
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inosine-5'-monophosphate dehydrogenase 2, how selective are they, and which programs against it are still in active trials?

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