Dihydrolipoyl dehydrogenase, mitochondrial

BE0000737ProteinHumansDLD

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). It is acted on by 5 drugs in DrugBank.

Gene name
DLD
UniProtKB entry
P09622Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
509 residues · 54,177 Da
Also known as
1.8.1.4 · Dihydrolipoamide dehydrogenase · GCSL · Glycine cleavage system L protein · LAD

Resolves to

Protein
UniProtP09622UniProt nameDLDH_HUMAN
Gene
HGNCHGNC:2898NCBI Gene1738GenBank307137GeneCardsDLD
Pharmacology
KEGGhsa:1738
Structure
PDB1ZMCPDB1ZMDPDB1ZY8
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Metabolic reactionDrug transformations it catalyses, substrate to product
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
32+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Dihydrolipoyl dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In