Ryanodine receptor 1

BE0000739ProteinHumansRYR1

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434,... It is acted on by 12 drugs in DrugBank.

Gene name
RYR1
UniProtKB entry
P21817Swiss-Prot
Cellular location
Sarcoplasmic reticulum membrane
Residues / weight
5,038 residues · 565,171 Da
Also known as
RYDR · RYR-1 · RyR1 · Skeletal muscle calcium release channel · Skeletal muscle ryanodine receptor

Resolves to

Protein
UniProtP21817UniProt nameRYR1_HUMAN
Gene
HGNCHGNC:10483NCBI Gene6261GenBank337722GeneCardsRYR1
Pharmacology
KEGGhsa:6261
Structure
PDB6UHIPDB6UHS
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
25GO termsFunction, process and component, as structured annotations
Sign in
9Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
95+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Ryanodine receptor 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In