Fibroblast growth factor receptor 2

BE0000748ProteinHumansFGFR2

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is acted on by 34 drugs in DrugBank.

Gene name
FGFR2
UniProtKB entry
P21802Swiss-Prot
Cellular location
Cell membrane
Residues / weight
821 residues · 92,024 Da
Also known as
2.7.10.1 · BEK · FGFR-2 · K-sam · Keratinocyte growth factor receptor

Resolves to

Protein
UniProtP21802UniProt nameFGFR2_HUMAN
Gene
HGNCHGNC:3689NCBI Gene2263GenBank31374
Pharmacology
IUPHAR/GtoPdb1809KEGGhsa:2263
Structure
PDB1DJSPDB1E0OPDB1EV2
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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17Clinical trialsTrials of drugs acting on it, by phase and status
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133GO termsFunction, process and component, as structured annotations
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172+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibroblast growth factor receptor 2, how selective are they, and which programs against it are still in active trials?

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