AEE-788

DB12558InvestigationalSmall molecule

AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.

Mechanism: Pharmacologically active on Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Receptor tyrosine-protein kinase erbB-2
Curator reviewed
Formula / weight: C₂₇H₃₂N₆ · 440.5832 g/mol (avg)
Code names: AEE 788 · GNF-Pf-5343 · NVP-AEE-788

Resolves to

Compound

Structure

InChIKeyOONFNUWBHFSNBT-HXUWFJFHSA-NSMILESCCN1CCN(CC2=CC=C(C=C2)C2=CC3=C(N2)N=CN=C3N[C@H](C)C2=CC=CC=C2)CC1

Targets

What you can answer from here — as of June 15, 2026

6Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with AEE-788, and which of those have an active Phase 3 trial?

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